{
  "_id": "6aca7cb7fe5cc25786e8a13c",
  "Package": "CleaningValidation",
  "Version": "1.0",
  "Title": "Cleaning Validation Functions for Pharmaceutical Cleaning\nProcess",
  "Authors@R": "c(\nperson(\"Mohamed Chan\", role = \"aut\"),\nperson(\"Wendy Lou\", role = \"aut\"),\nperson(\"Xiande Yang\", email = \"xyang1@apotex.com\", role = c(\"aut\", \"cre\"))\n)",
  "Description": "Provides essential Cleaning Validation functions for\ncomplying with pharmaceutical cleaning process regulatory\nstandards. The package includes non-parametric methods to\nanalyze drug active-ingredient residue (DAR), cleaning agent\nresidue (CAR), and microbial colonies (Mic) for non-Poisson\ndistributions. Additionally, Poisson methods are provided for\nMic analysis when Mic data follow a Poisson distribution.",
  "License": "GPL-3",
  "Encoding": "UTF-8",
  "RoxygenNote": "7.3.1",
  "Author": "Mohamed Chan [aut], Wendy Lou [aut], Xiande Yang [aut, cre]",
  "Maintainer": "Xiande Yang <xyang1@apotex.com>",
  "URL": "https://github.com/ChandlerXiandeYang/CleaningValidation",
  "Config/pak/sysreqs": "cmake make libicu-dev",
  "Repository": "https://chandlerxiandeyang.r-universe.dev",
  "Date/Publication": "2025-07-29 13:08:52 UTC",
  "RemoteUrl": "https://github.com/chandlerxiandeyang/cleaningvalidation",
  "RemoteRef": "HEAD",
  "RemoteSha": "b9e577aebcaa78182b81e82b2f8001551ebec17c",
  "RemoteSubdir": "CleaningValidation",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-10-10 16:48:33 UTC",
    "User": "root"
  },
  "_user": "chandlerxiandeyang",
  "_type": "src",
  "_file": "CleaningValidation_1.0.tar.gz",
  "_fileid": "https://r2.ropensci.org/7704fd21cc0d3fa05668d10bd59671e1333398b39cff09915ada5503cc785864",
  "_filesize": 181797,
  "_sha256": "7704fd21cc0d3fa05668d10bd59671e1333398b39cff09915ada5503cc785864",
  "_expires": "2027-01-18T17:58:13.000Z",
  "_created": "2026-10-10T16:48:33.000Z",
  "_published": "2026-10-10T17:58:15.121Z",
  "_buildurl": "https://github.com/r-universe/chandlerxiandeyang/actions/runs/38068968352",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_jobs": [
    {
      "job": 114262908142,
      "time": 171,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "11675973775"
    },
    {
      "job": 114262908193,
      "time": 151,
      "config": "linux-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11676303302"
    },
    {
      "job": 114262908156,
      "time": 231,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "11677542354"
    },
    {
      "job": 114262908191,
      "time": 189,
      "config": "macos-release-arm64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11678006091"
    },
    {
      "job": 114262355557,
      "time": 173,
      "config": "source",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11675863513"
    },
    {
      "job": 114262908200,
      "time": 102,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "11675817343"
    },
    {
      "job": 114262908190,
      "time": 130,
      "config": "windows-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "11676157195"
    },
    {
      "job": 114262908209,
      "time": 123,
      "config": "windows-oldrel-x86_64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "11676326990"
    },
    {
      "job": 114262908158,
      "time": 131,
      "config": "windows-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11676352024"
    }
  ],
  "_upstream": "https://github.com/chandlerxiandeyang/cleaningvalidation",
  "_commit": {
    "id": "b9e577aebcaa78182b81e82b2f8001551ebec17c",
    "author": "Xiande (Chandler) Yang <45187869+ChandlerXiandeYang@users.noreply.github.com>",
    "committer": "GitHub <noreply@github.com>",
    "message": "Update README.md",
    "time": 1753794532
  },
  "_maintainer": {
    "name": "Xiande Yang",
    "email": "xyang1@apotex.com"
  },
  "_distro": "resolute",
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 4.3.0",
      "role": "Depends"
    },
    {
      "package": "dplyr",
      "version": ">= 1.0.0",
      "role": "Imports"
    },
    {
      "package": "rlang",
      "role": "Imports"
    },
    {
      "package": "ggplot2",
      "version": ">= 3.3.3",
      "role": "Imports"
    },
    {
      "package": "cowplot",
      "version": ">= 1.1.1",
      "role": "Imports"
    },
    {
      "package": "dunn.test",
      "role": "Imports"
    },
    {
      "package": "boot",
      "role": "Imports"
    },
    {
      "package": "AER",
      "role": "Imports"
    },
    {
      "package": "lme4",
      "role": "Imports"
    }
  ],
  "_owner": "chandlerxiandeyang",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [],
  "_tags": [],
  "_stars": 1,
  "_contributors": [
    {
      "user": "chandlerxiandeyang",
      "count": 6,
      "uuid": 45187869
    }
  ],
  "_userbio": {
    "uuid": 45187869,
    "type": "user",
    "name": "Xiande (Chandler) Yang",
    "followers": 2,
    "description": "I am an AI-automation scientist on cleaning validation and process validation with academic background in biostatistics, mathematics, and computer science"
  },
  "_downloads": {
    "count": 432,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/CleaningValidation"
  },
  "_devurl": "https://github.com/chandlerxiandeyang/cleaningvalidation",
  "_searchresults": 0,
  "_rbuild": "4.6.1",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/CleaningValidation.html",
    "extra/contents.json",
    "extra/manual.pdf",
    "extra/readme.html",
    "extra/readme.md"
  ],
  "_homeurl": "https://github.com/chandlerxiandeyang/cleaningvalidation",
  "_realowner": "chandlerxiandeyang",
  "_cranurl": true,
  "_releases": [
    {
      "version": "1.0",
      "date": "2024-05-17"
    }
  ],
  "_exports": [
    "cv01_dfclean",
    "cv02_nonpro_oos_reswab",
    "cv03_usl_unification",
    "cv04_histogram_kde",
    "cv05_sw_norm_test_1",
    "cv06_sw_norm_test_2",
    "cv07_median_control_chart",
    "cv071_median_control_chart",
    "cv08_variability_chart",
    "cv09_kw_test",
    "cv10_dunn_test_vs_control",
    "cv11_vca_by_median",
    "cv12_kde_ppu",
    "cv13_poisson_test",
    "cv14_dispersion_test",
    "cv15_mic_mutate",
    "cv16_u_chart",
    "cv17_cusum",
    "cv18_ewma",
    "cv19_poisson_simple",
    "cv20_poisson_fixed",
    "cv21_poisson_mixed",
    "cv22_var_random_effect",
    "cv23_random_effect_coef",
    "cv24_vca_mic",
    "cv25_qbinom_ppu",
    "cv26_qpoisson_ppu",
    "cv27_anscombe_ppu",
    "cv28_freeman_ppu",
    "cv29_mic_ppu",
    "cv30_dar_car_mic_ppu",
    "Eq_CAR",
    "Eq_DAR",
    "Eq_Mic"
  ],
  "_help": [
    {
      "page": "CleaningValidation",
      "title": "Cleaning Validation Package",
      "topics": [
        "CleaningValidation",
        "CV"
      ]
    },
    {
      "page": "cv01_dfclean",
      "title": "Clean and preprocess residue data for stability and capability analysis",
      "topics": [
        "cv01_dfclean"
      ]
    },
    {
      "page": "cv02_nonpro_oos_reswab",
      "title": "Summarize Non-Process Related OOS and Reswab Data Which May Not Be Included in the Analysis",
      "topics": [
        "cv02_nonpro_oos_reswab"
      ]
    },
    {
      "page": "cv03_usl_unification",
      "title": "Unify USL Percentages for Specified Residue",
      "topics": [
        "cv03_usl_unification"
      ]
    },
    {
      "page": "cv04_histogram_kde",
      "title": "Plot Histogram with Kernel Density Estimate Curve",
      "topics": [
        "cv04_histogram_kde"
      ]
    },
    {
      "page": "cv05_sw_norm_test_1",
      "title": "Perform Shapiro-Wilk Normality Test",
      "topics": [
        "cv05_sw_norm_test_1"
      ]
    },
    {
      "page": "cv06_sw_norm_test_2",
      "title": "Perform Shapiro-Wilk Normality Test on Two Variables",
      "topics": [
        "cv06_sw_norm_test_2"
      ]
    },
    {
      "page": "cv07_median_control_chart",
      "title": "Median Control Chart and Density Plot",
      "topics": [
        "cv07_median_control_chart"
      ]
    },
    {
      "page": "cv071_median_control_chart",
      "title": "Median Control Chart",
      "topics": [
        "cv071_median_control_chart"
      ]
    },
    {
      "page": "cv08_variability_chart",
      "title": "Variability Chart for Cleaning Events",
      "topics": [
        "cv08_variability_chart"
      ]
    },
    {
      "page": "cv09_kw_test",
      "title": "Kruskal-Wallis Test for Residue Percentages",
      "topics": [
        "cv09_kw_test"
      ]
    },
    {
      "page": "cv10_dunn_test_vs_control",
      "title": "Dunn's Test for Residue",
      "topics": [
        "cv10_dunn_test_vs_control"
      ]
    },
    {
      "page": "cv11_vca_by_median",
      "title": "Variability Components Analysis by Median with Bootstrap",
      "topics": [
        "cv11_vca_by_median"
      ]
    },
    {
      "page": "cv12_kde_ppu",
      "title": "Calculate PPU using KDE density estimation",
      "topics": [
        "cv12_kde_ppu"
      ]
    },
    {
      "page": "cv13_poisson_test",
      "title": "Poisson Goodness-of-Fit Test",
      "topics": [
        "cv13_poisson_test"
      ]
    },
    {
      "page": "cv14_dispersion_test",
      "title": "Dispersion Test for Poisson Regression Models",
      "topics": [
        "cv14_dispersion_test"
      ]
    },
    {
      "page": "cv15_mic_mutate",
      "title": "Calculate Mic Statistics",
      "topics": [
        "cv15_mic_mutate"
      ]
    },
    {
      "page": "cv16_u_chart",
      "title": "Create a u-Chart for Poisson-distributed Data",
      "topics": [
        "cv16_u_chart"
      ]
    },
    {
      "page": "cv17_cusum",
      "title": "Create a CUSUM Chart for Poisson-distributed Data",
      "topics": [
        "cv17_cusum"
      ]
    },
    {
      "page": "cv18_ewma",
      "title": "Exponentially Weighted Moving Average (EWMA) Chart",
      "topics": [
        "cv18_ewma"
      ]
    },
    {
      "page": "cv19_poisson_simple",
      "title": "Poisson Fixed Effect Model Summary",
      "topics": [
        "cv19_poisson_simple"
      ]
    },
    {
      "page": "cv20_poisson_fixed",
      "title": "Poisson Fixed Effect Model",
      "topics": [
        "cv20_poisson_fixed"
      ]
    },
    {
      "page": "cv21_poisson_mixed",
      "title": "Poisson Mixed Effect Model Summary",
      "topics": [
        "cv21_poisson_mixed"
      ]
    },
    {
      "page": "cv22_var_random_effect",
      "title": "Extract Variance of Random Effects",
      "topics": [
        "cv22_var_random_effect"
      ]
    },
    {
      "page": "cv23_random_effect_coef",
      "title": "Extract Random Effect Coefficients",
      "topics": [
        "cv23_random_effect_coef"
      ]
    },
    {
      "page": "cv24_vca_mic",
      "title": "Variance Component Analysis for Microbial Counts",
      "topics": [
        "cv24_vca_mic"
      ]
    },
    {
      "page": "cv25_qbinom_ppu",
      "title": "Binomial Process Performance Calculation",
      "topics": [
        "cv25_qbinom_ppu"
      ]
    },
    {
      "page": "cv26_qpoisson_ppu",
      "title": "Calculate Process Performance Index using Poisson Distribution",
      "topics": [
        "cv26_qpoisson_ppu"
      ]
    },
    {
      "page": "cv27_anscombe_ppu",
      "title": "Process Performance Calculation using Anscombe's Transformation",
      "topics": [
        "cv27_anscombe_ppu"
      ]
    },
    {
      "page": "cv28_freeman_ppu",
      "title": "Calculate Ppu using Freeman's Transformation",
      "topics": [
        "cv28_freeman_ppu"
      ]
    },
    {
      "page": "cv29_mic_ppu",
      "title": "Calculate Mic Ppu with Five Methods",
      "topics": [
        "cv29_mic_ppu"
      ]
    },
    {
      "page": "cv30_dar_car_mic_ppu",
      "title": "Calculate DAR, CAR, and Mic Ppu Values and Identify the Overall Minimum",
      "topics": [
        "cv30_dar_car_mic_ppu"
      ]
    },
    {
      "page": "Eq_CAR",
      "title": "Equipment Cleaning Data for CAR",
      "topics": [
        "Eq_CAR"
      ]
    },
    {
      "page": "Eq_DAR",
      "title": "Equipment Cleaning Data for DAR",
      "topics": [
        "Eq_DAR"
      ]
    },
    {
      "page": "Eq_Mic",
      "title": "Equipment Cleaning Data for Microbial Bioburden",
      "topics": [
        "Eq_Mic"
      ]
    }
  ],
  "_readme": "https://github.com/chandlerxiandeyang/cleaningvalidation/raw/HEAD/README.md",
  "_rundeps": [
    "abind",
    "AER",
    "backports",
    "boot",
    "broom",
    "car",
    "carData",
    "cli",
    "colorspace",
    "cowplot",
    "cpp11",
    "Deriv",
    "doBy",
    "dplyr",
    "dunn.test",
    "farver",
    "forecast",
    "Formula",
    "fracdiff",
    "generics",
    "ggplot2",
    "glue",
    "gtable",
    "isoband",
    "labeling",
    "lattice",
    "lifecycle",
    "lme4",
    "lmtest",
    "magrittr",
    "MASS",
    "Matrix",
    "MatrixModels",
    "mgcv",
    "minqa",
    "modelr",
    "nlme",
    "nloptr",
    "nnet",
    "numDeriv",
    "pbkrtest",
    "pillar",
    "pkgconfig",
    "purrr",
    "quantreg",
    "R6",
    "rbibutils",
    "RColorBrewer",
    "Rcpp",
    "RcppArmadillo",
    "RcppEigen",
    "Rdpack",
    "reformulas",
    "rlang",
    "S7",
    "sandwich",
    "scales",
    "SparseM",
    "stringi",
    "stringr",
    "survival",
    "tibble",
    "tidyr",
    "tidyselect",
    "timeDate",
    "urca",
    "utf8",
    "vctrs",
    "viridisLite",
    "withr",
    "zoo"
  ],
  "_score": 2.6989700043360187,
  "_indexed": true,
  "_nocasepkg": "cleaningvalidation",
  "_universes": [
    "chandlerxiandeyang"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.0",
      "date": "2026-10-10T16:50:46.000Z",
      "distro": "resolute",
      "commit": "b9e577aebcaa78182b81e82b2f8001551ebec17c",
      "fileid": "https://r2.ropensci.org/6fa1f694db689d91a51d76f782a8ff6e0532e60d675dc4618ac7793dd413fb47",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/chandlerxiandeyang/actions/runs/38068968352"
    },
    {
      "r": "4.6.1",
      "os": "linux",
      "version": "1.0",
      "date": "2026-10-10T16:50:38.000Z",
      "distro": "resolute",
      "commit": "b9e577aebcaa78182b81e82b2f8001551ebec17c",
      "fileid": "https://r2.ropensci.org/c6793954cf277aca26a51dc090ba810c2d1d955bedeb1b8adb5f0930f683102b",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/chandlerxiandeyang/actions/runs/38068968352"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.0",
      "date": "2026-10-10T17:56:24.000Z",
      "commit": "b9e577aebcaa78182b81e82b2f8001551ebec17c",
      "fileid": "https://r2.ropensci.org/25634917a3d4f58cf321d1c258c667a00096f78b6946d17478e87adc6183490d",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/chandlerxiandeyang/actions/runs/38068968352"
    },
    {
      "r": "4.6.1",
      "os": "mac",
      "version": "1.0",
      "date": "2026-10-10T17:52:27.000Z",
      "commit": "b9e577aebcaa78182b81e82b2f8001551ebec17c",
      "fileid": "https://r2.ropensci.org/1f69f3aaacae5240fc25ecfebc1500c206103b14713fe74361afc20b5f01902f",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/chandlerxiandeyang/actions/runs/38068968352"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.0",
      "date": "2026-10-10T16:50:39.000Z",
      "commit": "b9e577aebcaa78182b81e82b2f8001551ebec17c",
      "fileid": "https://r2.ropensci.org/cbc2fecd751133d0d18c6648889867695e5fb6e30acbd6a4a799778ff1d9b488",
      "status": "success",
      "buildurl": "https://github.com/r-universe/chandlerxiandeyang/actions/runs/38068968352"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.0",
      "date": "2026-10-10T16:49:53.000Z",
      "commit": "b9e577aebcaa78182b81e82b2f8001551ebec17c",
      "fileid": "https://r2.ropensci.org/443422d144d87f9c55a8d921d87444fd5ca8684f594a22b3b4dae86535dbabf2",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/chandlerxiandeyang/actions/runs/38068968352"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "1.0",
      "date": "2026-10-10T16:49:47.000Z",
      "commit": "b9e577aebcaa78182b81e82b2f8001551ebec17c",
      "fileid": "https://r2.ropensci.org/ef72def4dbe11909d60b91bc8d4b990e2e0df58a305bce17ef6b706577dbac88",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/chandlerxiandeyang/actions/runs/38068968352"
    },
    {
      "r": "4.6.1",
      "os": "win",
      "version": "1.0",
      "date": "2026-10-10T16:49:57.000Z",
      "commit": "b9e577aebcaa78182b81e82b2f8001551ebec17c",
      "fileid": "https://r2.ropensci.org/ca32bce9378aba3d0be11db8ca3c7f7f5febf30d4e1198b38b41ffea56bbbf46",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/chandlerxiandeyang/actions/runs/38068968352"
    }
  ]
}